Oxidation of plasma free fatty acids in nonshivering thermogenesis of rats treated chronically with norepinephrine and thyroxine.
نویسندگان
چکیده
In rats treated chronically with norepinephrine and thyroxine, enhanced nonshivering thermogenesis was observed, with a concomitant increase in the utilization of plasma free fatty acids (FFA). The increased utilization of plasma FFA was characterized by a more preferential increment in the oxidation of FFA in tissues rather than that in the uptake of FFA by tissues. These biochemical findings were accompanied by an increased mitochondrial mass in red fibers of skeletal muscle. Both biochemical and morphological changes of a similar nature were found in cold-acclimated rats.
منابع مشابه
Effects of norepinephrine and thyroxine on the turnover rate of plasma free fatty acids.
Effects of norepinephrine infusion on rectal temperature, plasma free fatty acids (FFA) concentration and its turnover rate were studied in rats treated chronically with norepinephrine, thyroxine, or both. Chronic treatments with these hormones resulted in greater increases in rectal temperature and FFA turnover rate in response to norepinephrine as compared with the alterations in controls. No...
متن کاملThe Effects of Simvastatin on Free Fatty Acids Profile in Fructose-fed Insulin Resistant Rats
Backgrounds: Type 2 diabetes mellitus is the most common metabolic disease and free fatty acids, as signaling molecules, can play a crucial role in the development of it. Different free fatty acids, through various cell membrane receptors, induce different effects on metabolic pathways and thereby affect insulin sensitivity. Simvastatin is a cholesterol decreasing drug prescrib...
متن کاملThermoregulatory responses of the inbred heat-tolerant FOK rat to cold.
The responses of inbred heat-tolerant FOK rats to cold were compared with those of Wistar King A/H (WKAH) and Std:Wistar (WSTR) strains. The fall of colonic temperature during cold exposure was unexpectedly smaller in FOK than in other groups, but the onset of shivering was delayed in FOK. Norepinephrine (NE)-induced in vivo oxygen consumption and the mitochondrial uncoupling protein 1 level of...
متن کاملFatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue.
Nonshivering thermogenesis in brown adipose tissue (BAT) generates heat through the uncoupling of mitochondrial beta-oxidation from ATP production. The principal energy source for this process is fatty acids that are either synthesized de novo in BAT or are imported from circulation. How uptake of fatty acids is mediated and regulated has remained unclear. Here, we show that fatty acid transpor...
متن کاملEffects of norepinephrine on uptake and oxidation of plasma free fatty acids in cold-acclimated rats.
In order to know the mode of action of norepinephrine in enhanced utilization of plasma free fatty acids (FFA) in cold acclimation, albumin-bound 14C-palmitate was infused intravenously at a constant rate into cold- and warm-acclimated rats under pentobarbital anesthesia with and without norepinephrine infusion. Rectal temperature, CO2 output and plasma FFA, from which the rates of FFA uptake a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Japanese journal of physiology
دوره 31 5 شماره
صفحات -
تاریخ انتشار 1981